improving pain management strategies
The PRECISE Analgesia study is designed to improve pain management for children undergoing major inpatient surgery.
It includes two randomized clinical trials that compare two different analgesia approaches to surgical pain relief in children undergoing cardiac surgery (PRECISE Cardiac Trial) and idiopathic scoliosis spine fusion surgery (PRECISE Spine Trial), respectively. One analgesia approach uses a standardized multidose methadone-based pain management, while the other follows the current standard of care analgesia without methadone.
Researchers will assess how well each pain management approach controls acute surgical pain, reduces opioid-related side effects, and supports overall recovery. Participants will be monitored for up to three months after surgery to understand the long-term effects of each treatment.
By improving pain management strategies, the PRECISE Analgesia study aims to enhance recovery, reduce the risks associated with opioid medications, and contribute to safer pain relief options for all children undergoing surgery.
safer pain relief options
The PRECISE Analgesia study will enroll about 1,000 children across multiple medical centers in the US.
Researchers will follow participants for three months after surgery to evaluate pain relief, recovery, and opioid-related effects.
