About
About
Improving Pain Management Strategies for Children
Safer Pain Relief Options for Children Undergoing Surgery
The PRECISE Analgesia study will enroll about 1,000 children across multiple medical centers in the US. The PRECISE Cardiac Trial will include 500 children from four clinical sites, and the PRECISE Spine Trial will enroll 500 participants from five clinical sites.
Participants will receive pain management during surgery and hospital stay using either a standardized methadone-based approach or the standard of care analgesia without methadone. Researchers will follow participants for three months after surgery to evaluate pain relief, recovery, and opioid-related effects.
Beyond comparing these two pain management approaches, the PRECISE Analgesia study aims to develop safer, more effective pain management strategies while reducing opioid use. By identifying which children benefit most from each approach, PRECISE Analgesia seeks to improve surgical pain control for millions of children.
The PRECISE Analgesia study is part of the NIH HEAL KIDS Pain (Helping to End Addiction Long-term Knowledge, Innovation, and Discovery Studies) – Acute Pain Clinical Trials (APCT) program, which support new clinical research programs to evaluate innovative therapies for acute pain management in children. The PRECISE Analgesia study is funded by the National Institute of Child Health and Human Development (NICHD). Learn more at HEAL Initiative.